So here comes the question.
After decades of clinical work, have these veterans never really considered the causes of gastric ulcers? Have they never considered taking out a microscope one day to carefully examine the gastric mucosal specimens to see if there are any bacilli?
Why have they not discovered a problem that an ordinary internal medicine graduate student in Australia can find?
Ultimately, this is still neglecting scientific research.
Without a solid medical foundation, it is difficult to improve clinical diagnosis and treatment skills.
You know how to treat it, but you also have to know why you're using it and how the disease occurs. If you don't understand this, you'll only know how to use it, and your skills are limited.
Even decades later, the "guidelines" issued by various medical associations in China are, to put it bluntly, copied from foreign guidelines. There is almost no clinical experience that is truly innovative of our own. This is really embarrassing.
This is where we suffer a loss. We know what to do and we are very good at it, but we often can't explain why we do it. We just follow others' lead and do what they say.
It is almost impossible for the Nobel Prize in Physiology or Medicine to be awarded to a clinician, which shows that only abroad are places that truly value basic medical research.
This study on Helicobacter pylori also falls within the scope of basic medical research, so this is why two Australian doctors won the Nobel Prize at the same time in Chen Xia's previous life.
After the Director of the Department of Science and Education introduced the leaders and medical experts present, the meeting got down to business, with Chen Chun as the keynote speaker.
Chen Chun took a deep breath. He appeared confident on the surface, but he was actually very panicked inside.
Several senior professors were also quite surprised that the first author of the Helicobacter pylori paper was so young. Their suspicions grew, and they decided to ask for clarification later.
Old intellectuals cannot tolerate any grain of sand in their eyes.
Zheng Haidong also came along this time because he was doing the research and reverse engineering of proton pump inhibitors, which are the key to the treatment of Helicobacter pylori, so the Provincial First Hospital also asked him to go along.
He looked at his girlfriend who seemed so confident on the surface, and he felt so proud in his heart.
Chen Chun turned on his own slide projector and began to explain. Of course, being humble first was a necessary procedure, as Chinese people are just so polite.
Or... hypocrisy...
"We occasionally found an unidentified bacillus in tissue specimens from patients with stomach problems. To this end, we specifically extracted gastric mucosal specimens from inpatients in the gastroenterology departments of seven hospitals, including the First, Second, Third, Fourth, and Fifth Zhijiang Provincial Hospital, Yuezhou People's Hospital, and Yuezhou Second Hospital.
A total of 200 specimens were collected from patients with common gastritis, and 140 of them were found to contain this unidentified bacillus, accounting for 70%;
Among 200 specimens from patients with gastric ulcer, 190 were found to have unidentified bacteria, with an average infection rate of 95%. Among them, the infection rate of Helicobacter pylori in patients with duodenal ulcer was as high as 90% to 100%, and that in patients with gastric ulcer was 80% to 90%.
A total of 50 specimens were extracted from gastric cancer patients, and unidentified bacteria were observed in 44 of them, accounting for 88%.
In other words, this unidentified bacillus is present in the vast majority of patients with stomach problems. So, is there a necessary connection or relationship between the presence of the bacillus and the onset of stomach problems? We are currently conducting research on this step.”
Professor Sang Caihua of Peking University Third Hospital raised a question:
"You've only discovered the existence of this unidentified bacillus, but is there a necessary connection between this bacillus and stomach problems? This doesn't necessarily equate to a true relationship, right?"
Chen Chun nodded and answered very seriously:
"Professor Sang's questions are exactly what our research team has in mind, and they are also the reason Xiangjiang Pumpkin Vine Company has entrusted us with further research.
We found that this is because the harmful substances produced by Helicobacter pylori can damage the gastric mucosa and cause gastric mucosal dysfunction. One of them is ammonia, chemical name NH3. When ammonia comes into direct contact with the gastric mucosa, it can cause mucosal bleeding.
Our experiments have shown that when Helicobacter pylori comes into contact with gastric cells, the cells will stop functioning one after another. After 24 hours, the toxins released by Helicobacter pylori cause damage to the gastric mucosal cells, which in turn produces white vacuoles and causes gastritis.
At the same time, Helicobacter pylori produces a large amount of highly active urease, which breaks down urea into ammonia and carbon dioxide. Ammonia can neutralize gastric acid, allowing the bacteria to survive in the highly acidic stomach.
The accumulation of urease and ammonia can also damage the gastric mucus layer and mucosal cells, destroy the mucus-bicarbonate barrier, and cause proton reflux to the mucosa, leading to the occurrence of peptic ulcers.
If Helicobacter pylori persists and inflammation persists, and the body is then exposed to external environmental stress, the mucus that protects the stomach lining will not function properly. As a result, gastric acid damages the gastric mucosa, turning it into a gastric ulcer. Ulcers can lead to gastric bleeding, which can then worsen into a herniated hole and eventually cause gastric cancer.
Professor Xu Guangzhou of Union Hospital was shocked:
"So, your research not only discovered the presence of this unidentified bacillus in various stomach disease patients, but also explored the mechanism by which it causes disease? So in-depth?"
Several other experts also discussed the matter, finding it unbelievable. After all, it had only been more than two months since the project was reported to the Ministry of Health.
They could never have imagined that in such a short period of time, relying on the scientific research capabilities of two hospitals and a university, they could have carried out research to such an in-depth level.
Which medical research does not require years or even decades of unremitting efforts, a lot of money and the day and night work of a large number of researchers to produce some results?
Is it possible that the laboratory of the Provincial First Hospital and Yuezhou People's Hospital is cheating?
If Chen Xia heard their conversation, he would definitely answer in his heart:
"That's cheating, isn't it? These theoretical studies have long been told to Chen Chun. What she needs to do is not exploration or research, but just repeating the same steps. How can it not be fast?"
Chen Chun nodded again and answered the question very patiently:
"Yes, Professor Xu, the reason our research progress is so fast is because it is based on a series of research results that Xiangjiang Pumpkin Vine Company has already conducted. It's like we are standing on the shoulders of giants."
Everyone turned their eyes to the smiling Chen Shuqin, wondering why such a groundbreaking research topic was not being studied in Hong Kong, but instead went all the way to the mainland to seek cooperation.
Some people, who are highly vigilant and obsessed with class struggle, wonder if there is some conspiracy here. Capitalism is determined to destroy us.
Chen Shuqin is such a smart person.
When Chen Chun said those words, she knew what other people's doubts would be. No one would understand why Hong Kong would give up such a good opportunity.
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