Chapter 469 Pharmaceutical Antipyretic Tablets



Jiang Zhi lives on the mountain, and the happiest person is Peppa Pig. Every day, she goes out for a stroll and then rushes home to watch over her.

If you can beg for food and pets, and get a brush to scratch your itch, you'll be so happy you'll be lying in a muddy mess.

Chunfeng was also very happy. Qiaoyun had left, and while living on the mountain was peaceful, she was also very lonely and wanted to hear some new things.

Jiang Zhi spoke her mind, recounting everything she had seen and heard during her trip to Jincheng Prefecture.

The two people in front of her were only in their early twenties. If possible, Jiang Zhi hoped that they could visit the village more often and not stay in the mountains in isolation.

But... when she thought of Chunfeng's family coming to Xujia Village again on the second day of the Lunar New Year, she swallowed her words.

The last time Chunfeng's family came to Xujia Village was shortly before the New Year when Chunfeng's parents brought people to demand her return and caused a huge scene.

That time, he was well-prepared. Not only did he obtain Chunfeng's divorce papers, but Xu Changming also verbally abused Chunfeng's parents, causing a bitter argument between the two sides.

They thought Chunfeng's parents were going to sever ties and never see each other again, but unexpectedly, Chunfeng's mother came again on the second day of the Lunar New Year.

Xiaoman's family was not in the village; they were all spending the New Year on the mountain. Even Errui and his sons, Tiangui and Tiantao, were visiting Laoyun Cliff to offer New Year's greetings and were not in the village.

Jiang Zhi was too tired from traveling back by car on the night of the 29th of the year, and Qiao Yun was pregnant, so she stayed at home. Then Chun Feng's family came and went to Si Shui Tang.

This time, Chunfeng's mother didn't make a fuss. She smiled and brought gifts to Chunfeng's house, saying she had come to take Chunfeng and her daughter back to Chunfeng's parents' home for the New Year.

Having gone through so many life-and-death situations before, Jiang Zhi knew that Chunfeng didn't want to go back to her parents' home. However, not wanting to offend someone who was smiling, she politely declined, saying, "Sister-in-law, Chunfeng has to take care of Dazhu right now, so it's inconvenient for her to go. She can go back when Dazhu is feeling better."

Let's leave it at that for now, and Chunfeng can decide for herself whether or not to go back to her parents' home later.

Accompanying Chunfengniang was her second aunt, who had inexplicably argued with Qinshi last time she came, and ended up leaving empty-handed without accomplishing anything.

Perhaps seeing that Jiang Zhi's temper was better than last time, and that it was a holiday when one shouldn't fight or get angry, Chunfeng's second aunt immediately said sarcastically, "Xu Dazhu, that cripple, should think things through... Humph, if he's not good for the rest of his life, our Chunfeng might never come back to her parents' home again!"

Jiang Zhi was furious. Some people are like stubborn mules; they won't be satisfied until they're beaten up. She immediately said coldly, "Speaking such vile words will only bring you bad luck. Get out of here! Don't show your face in front of me. Just seeing you is an eyesore. Don't make me call someone to beat you up."

Jiangzhi doesn't discriminate between meat and vegetables; even during the Lunar New Year, they're quick to shout and kill.

Seeing the village chief turn hostile, Chunfeng knew she wouldn't see her daughter, and being too shy, Chunfeng had no choice but to leave!

This matter didn't cause much of a stir, and a few days later Jiang Zhi told Xiao Man about it.

Later... two months have passed since then, and Chunfeng's family has not come again.

Jiang Zhi lived on the mountain and checked on Xu Dazhu's back injury.

After three years of cultivating himself with various herbs on the mountain and exercising on his own, Xu Dazhu can now stand steadily on both legs.

They can still take small steps, and with the help of crutches, they can move around freely.

"Auntie, I can do everything easily now." Xu Dazhu was very satisfied with his recovery. Although he was not yet a normal person in terms of physical strength, he felt that he was not much worse than others.

I've gotten used to walking, and my range of motion is quite large, so I can go up and down stairs with ease.

After stopping the production of Tibetan incense on the mountain in early autumn, Xu Dazhu rejuvenated the slope that had been parched and died last year.

Last summer, a drought caused reduced grain production at the foot of the mountain and a complete crop failure on the mountain. Only some vegetables were salvaged from the terraced fields.

Knowing that the soil layer in the mountains is thin and not drought-resistant, the seedlings will die if it doesn't rain for ten days or half a month.

So every day, Xu Dazhu climbed up and down the slope, using rubble to build small terraces on the slope, each one small in size, like fish scales.

Now in February, the wheat seedlings in the repaired fish-scale fields are growing lush and green, all thanks to him.

On Old Cloud Cliff, Jiang Zhi began to seriously research and develop new drugs.

The village is too crowded and chaotic, the pharmacy has no empty stoves, and the steamer used to distill essential oils is also on the mountain. Only the quiet Laoyun Cliff is the most suitable place to make medicine.

She wasn't just placating Magistrate Zhang when she said the pharmacy wouldn't be doing manual labor; she genuinely meant they had to produce several kinds of medicine.

After feeding the pigs and chickens, Chunfeng and Dazhu would come over to help her.

The "miracle water" made from willow bark in summer can combat drought, ultimately due to the effect of salicylic acid.

Salicylic acid's most significant effects are in relieving fever and pain, but it is very irritating to the gastric mucosa, and long-term use can lead to gastrointestinal ulcers and bleeding.

Therefore, the laboratory later used salicylic acid as a raw material, and added acetic anhydride and concentrated sulfuric acid to directly react and produce aspirin with slightly fewer side effects.

Jiang Zhi couldn't make chemical pills, so she could only try to find a way to make them from willow bark.

For ordinary people in this era, severe high fever and pain can be fatal; stomach damage is secondary.

After all, if you're dead, there's not much point in keeping your stomach intact.

As for long-term use, that's even more impossible. Fever reducers are not meant to be taken casually; they can only be used for emergency treatment and to save lives.

The ingredients to be used are: honeysuckle, wild chrysanthemum, belamcanda chinensis, aspirin, etc.

[Historical Origin] "Anti-Cold Tablets No. 4"

[Source of the prescription] Beijing Pharmaceutical Factory

Preparation method: First, weigh and prepare all the Chinese herbs you brought, then boil them.

Honeysuckle, wild chrysanthemum, and iris were extracted three times using the boiling extraction method. For the first extraction, the mixture was soaked in six times the amount of water for half an hour, and then boiled for one hour.

For the second and third times, add five times the amount of water each time and boil for half an hour each time. Combine the filtrates from the three boilings, let them stand, and then boil and concentrate them to a 1:1 ratio.

Unlike making powdered medicine, this time it also needs to be converted to a solvent, which means adding high-concentration alcohol to the concentrate at a ratio of 60% and soaking for 48 hours.

During this time, Jiang Zhi was busy grinding willow wood powder.

The highest concentration of salicylic acid in willow trees is not found in the bark, but in the thin, white, woody layer beneath it, which is dried, ground, and sieved through the finest sieve.

After the alcohol has been soaked for the required time, Jiang Zhi will need to recycle the alcohol.

As for how it's recycled, the answer is distillation!

So Chunfeng and Xu Dazhu watched as Jiang Zhi repeatedly boiled, soaked, and steamed these medicinal liquids. After the alcohol was extracted, the liquid was concentrated into a paste once again.

Finally, mix starch, willow powder, and ointment into fine granules.

Previously, the tablets were not hard enough. A standard tablet should not break when dropped from a height of one meter. To meet this standard, talcum powder had to be added to the tablet powder.

Having experience in making mosquito coils, Jiang Zhi has now changed the method of pressing the coils into tablets.

Beforehand, drill holes of various sizes and specifications on a smooth wooden board, then fill the holes with medicine powder of appropriate dryness and moisture, which has been mixed with talcum powder, and then press it firmly with a die. The medicine tablets are then dried.

Because she was worried about upsetting her stomach, and also to have a clear label, Jiang Zhi patiently coated each pill with an orange-red sugar coating.

The coating of tablets requires gelatin, which is produced by the degradation of collagen in connective tissues such as animal skin, bones, and muscle membranes into white or pale yellow, translucent, slightly glossy flakes or powders.

This is something that carpenters have.

Ancient houses also needed glue, but the glue they used in woodworking had to be boiled and used simultaneously, and it would solidify as soon as it cooled. They used natural gelatin, which was pollution-free.

Jiang Zhi will naturally use it as well.

Then, a small amount of boiled syrup is added, along with natural coloring, to create various colored pills.

Natural pigments include amaranth, carmine, indigo, and orange, all of which are readily available.

By the time the first batch of antipyretics was ready, it was already mid-March, another spring season of blooming flowers and singing birds.

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