Chapter 810 Boss Chen's Life-Extending Miracle Medicine! I Don't Want to Die a Wimpy Death!
Inside the Orange Biotechnology R&D Center.
Chen Yansen took the extracted and dried gamma-oryzanol and rice polyphenols and went to another laboratory.
He operated the equipment and added phosphatidylserine, povidone K30 and sodium dodecyl sulfate one by one. Using liposome manufacturing equipment, he performed rotary evaporation to form a film and microfluidization. After adding 10% trehalose and 3% mannitol, and then freeze-drying at low temperature, he finally obtained 12.4 grams of active ingredients.
Simply package it in enteric-coated capsules, aluminum-plastic packaging, and then seal it with nitrogen to create a targeted drug that can inhibit and repair Aβ deposition, Tau protein hyperphosphorylation, and neuroinflammation.
Several of the drug ingredients were supplied by Baichen Technology, a North American pharmaceutical company he had just acquired.
As for the effectiveness of this product, intervention experiments are needed first to detect changes in lesions such as Aβ plaques and inflammatory factors.
Its core function is to regulate reductase, improve cerebral blood flow, and awaken cell activity, thereby clearing plaques and tangles in brain neurons.
There are only two types of causes for Alzheimer's disease.
The first possibility is that "waste" has accumulated in the brain, and a substance called amyloid precursor protein is abnormally cleaved, producing toxic β-amyloid protein fragments.
These fragments come together to form plaques that accumulate between neurons.
Ultimately, this disrupts neuronal signal transmission, triggers an inflammatory response, and leads to neuronal death.
In addition, inside neurons, there is a protein called Tau, which acts like a skeleton to support the neuron's transport system.
In Alzheimer's disease, the Tau protein undergoes abnormal phosphorylation, twisting into thin filaments that become tangled together.
These tangles disrupt the cell's transport system, preventing the normal transport of nutrients and waste products, leading to neuronal apoptosis.
The second type is neuroinflammation, where glial cells in the brain are overactivated while clearing waste, releasing inflammatory factors that attack healthy neurons and exacerbate the damage.
At this point, top medical institutions in both China and Europe and America only have inhibitory drugs for Alzheimer's disease, which can alleviate symptoms but cannot cure it.
The pale yellow powder extracted by Chen Yansen can repair neurons, alleviate the symptoms of severely ill patients, and may even lead to a complete recovery if taken long-term.
While busy with these tasks, he simultaneously informed Song Yongping, the head of Orange Medical, about the general situation of the new drug, and asked him to contact the National Medical Products Administration to apply for clinical trials.
"Neuro Guard, the brain shield?"
Song Yongping was originally a professional agent for a Hong Kong Island medical company. At the beginning of the year, he was recruited by Chen Yansen to manage Orange Medical's hospitals, pharmaceutical companies, and sales network.
He was originally a medical technician, so he could understand some of the drug ingredients to some extent.
Gamma-oryzanol contains active ingredients such as cycloartenol ferulic acid ester and sterol ferulic acid ester, but he did not expect that this stuff could actually inhibit Aβ-induced neuroinflammation.
The active substances in rice polyphenols, such as ferulic acid, γ-oryzanol, and p-coumaric acid, can also reduce iron-induced oxidative stress and Aβ protein deposition, and repair mitochondrial and brain nerve function.
"Boss, is this a new drug developed by Baichen?"
Song Yongping asked curiously.
A year ago, he heard that BioCenter, a pharmaceutical giant in the United States, was developing a new type of drug.
Not long after, his boss reached an agreement with several financial giants, including Blackstone and BlackRock, to acquire Baichen Pharmaceuticals at the Davos Economic Forum.
Therefore, his first reaction was that this was a product of scientific research in North America.
"I guess so. You should go through the procedures first."
Chen Yansen gave an ambiguous answer.
In fact, Baichen Pharmaceuticals did provide some assistance and gave him a direction, which enabled him to accelerate the research and development of Brain Shield.
Of course, this is also inseparable from the successful cultivation of Super Rice 2000, which has increased the content of γ-oryzanol and rice polyphenols by dozens of times.
Otherwise, only 0.1 to 0.2 grams of active ingredients can be extracted from one kilogram of ordinary rice, which would be too costly.
"Okay, boss." Song Yongping didn't ask any more questions and readily agreed.
After hanging up the phone, Chen Yansen put the powder into capsules, then sealed them, making a total of 24 brain shields.
By the time he walked out of the research and development center, it was already dark.
He then got into the car and sent a message to Song Yuncheng.
A moment later, Xiao Chengzi, dressed in a white blazer, a skirt, and black sheepskin soft-soled shoes, walked out of the elevator at a leisurely pace, then opened the back door of the Hongqi L5 and darted inside.
"Where should we eat?" Song Yuncheng put down her laptop bag and smiled slightly at Chen Yansen.
It was obvious that she planned to have work to do after she got home.
"Is Pinduoduo very busy lately?" Chen Yansen raised his hand and pinched Song Yuncheng's cheek as he asked.
"The 618 shopping festival is coming soon. It's similar to last year's Singles' Day. We'll be organizing a global e-commerce festival, which means we'll have a lot more work to do."
Song Yuncheng felt a tickle on her cheek, smiled sweetly, and rubbed her face against Chen Yansen's fingers.
Here, this is for you.
Chen Yansen handed two blister packs of sealed capsules to Song Yuncheng.
"What's this?"
Song Yuncheng asked with a puzzled look.
"A new drug, incorporating a large number of brain nerve repair ingredients, can improve memory and repair nerve nodules in the brain..."
Chen Yansen explained slowly.
"Do you think I'm stupid?" Song Yuncheng asked blankly.
"Bang!"
Chen Yansen chuckled and habitually tapped her on the head, saying, "It's for your brother."
Upon hearing this, Song Yuncheng's eyes lit up. She raised her little head and stared intently at Chen Yansen, saying, "You mean, it can treat toxic encephalopathy?"
"We haven't done clinical trials yet," Chen Yansen replied with a smile.
Clinical trials, marketing authorization applications, and technical reviews are procedures; whether or not they are approved will not affect the efficacy of the drug.
The implication is that the two strips of medicine in front of them are not compliant and carry certain risks.
"I believe you." Song Yuncheng carefully put it in her bag, planning to take it home tomorrow.
“Take one pill a week. It’s hard to say exactly how long you need to take it, but I estimate it will take at most a year for your brother’s condition to improve.”
Chen Yansen said in an extremely conservative manner.
He had deduced the effects of this drug using the overclocking thinking of the Planck clock. Just 24 pills were enough to restore the memory of a mouse artificially induced with Alzheimer's disease, and various pathological indicators also showed a significant decrease.
However, these are just the results he deduced using various data and information. He doesn't dare to say for sure whether there are other influencing factors in reality.
"Master, thank you."
Song Yuncheng held Chen Yansen's arm and said with heartfelt gratitude.
"Old Huang, drive!"
Chen Yansen spoke to Huang Boxiang, who was staring straight ahead.
After saying that, he leaned back comfortably, held Xiao Chengzi in his arms, and looked out the car window at the colorful clouds.
In the distance, a faint strain of an old song drifted by.
Where would I be if I hadn't met you?
How are you living your life? Should you cherish it?
"Perhaps I know someone, and I'm living an ordinary life."
"I wonder if, too, there are loves as sweet as honey..."
On the other side.
Song Yongping is busy organizing materials for applying for clinical trials, and he also plans to submit applications in North America, Europe and other places.
If you want to list your products on the market, you have to go through the legal and compliant procedures.
As the first drug sold by Baichen Pharmaceuticals, NeuroGuard attracted considerable attention when it appeared on the approval lists of drug regulatory agencies in Europe and the United States.
A targeted drug that can repair brain nerves?
How to extract active ingredients from Super Rice 2000?
If it were any other pharmaceutical company, NeuroGuard would not have made much of a splash. However, because it is backed by the Senlian Group and was acquired by Chen Yansen himself, many people want to know the specific efficacy of this product.
After all, as people get older, even if they don't develop Alzheimer's disease, they will experience memory decline.
For those who possess enormous wealth, who would willingly allow themselves to become a puppet to be manipulated?
To put it bluntly, once you lose your normal thinking ability, you won't trust anyone, not even your own children, let alone your competitors.
For example, Benson, the owner of the New Orleans Saints and Pelicans, was diagnosed with Alzheimer's disease at this time, and his mind was often clear, but would often fall into confusion.
His net worth is a staggering $15 billion, making him a highly influential super-rich individual in North America.
The current problem is that his daughter and grandson are accusing him in court of having Alzheimer's disease, which has caused cognitive decline, and are trying to get him to amend the trust decision in order to receive a larger share of the profits.
"Fuck! I'm not dead yet!"
Benson had just returned to his luxurious villa from the courthouse, cursing incessantly.
He slammed his cane on the floor with a loud thud, his anger almost overflowing.
Just as the lawyer standing nearby was about to intervene, Benson's expression suddenly changed, and he looked at him with a puzzled look, asking, "Cronin, what are you doing here?"
Oh no, he's having another episode!
Cronin muttered to himself, but in front of his employer, and with good professional manners, he still recounted what had happened that day.
Although the company court ultimately ruled that Benson's "brain is normal" and dismissed the charges brought by his daughter and grandson, his condition is worsening, and he may be completely unconscious when he appears in court again.
"Mr. Cronin, thank you for today's case."
After sorting out his thoughts, Benson politely thanked him, a cold glint flashing in his eyes.
Now he is like an aging lion king on the African savanna, and everyone, including his relatives, wants to take a bite out of him.
It would be a lie to say I'm not upset.
But he didn't want to die in a daze. Given the current trend, once he lost his autonomy, he might suffer some humiliation and torment.
After the lawyer left, Benson called his medical team.
Are there any new treatment options or medications for Alzheimer's disease?
Benson asked with a gloomy expression.
Today's events have severed ties between him and his daughter and grandson. He fears that if things continue like this, he might not live to see a natural death, and someone will arrange an accident for him.
"There are many new drugs, but they can only inhibit or alleviate symptoms, not repair or cure them."
The head of the medical team thought for a moment and then said.
However, a nurse behind him suddenly spoke up: "Mr. Benson, I heard that Orange Medical's subsidiary, Baichen Pharmaceuticals, has submitted a new drug application that can repair damaged brain nerves, but it has not yet undergone clinical trials."
Orange Healthcare?
Benson was taken aback and squinted as he tried to recall.
When he finally connected the company with Chen Yansen and Senlian Group, he was immediately energized and a glimmer of hope welled up in his heart.
"Make arrangements for me, I need to go to China immediately."
A moment later, Benson made his decision.
Life and death are difficult hurdles for ordinary people to overcome, but even though he has lived to be 90 years old, he still does not want to die.
...
...
The next day, Chen Yansen went to work as usual.
Aside from meetings, he spends most of his time in the lab, dedicating his energy to the cultivation of Ora Gold 940 soybeans.
During lunch break, Meng Yun knocked on his office door and informed him that Benson was coming to visit.
Chen Yansen did not agree directly. Instead, he used Moss to search for the other party's information and recent situation, and immediately understood the other party's little scheme.
So I nodded and set aside 15 minutes for the other person.
After a short rest, we went into the room where the Moss super server was located to continue refining the design work of the rocket, payload bay, and satellite.
Meanwhile, in a private plane over the Pacific Ocean, Benson was deep in thought.
First, will Chen Yansen give him face?
Second, is NeuroGuard actually effective?
As for the fact that the drug is not yet on the market, he is not worried at all. He will purchase it under the guise of research and development to reduce Orange Medical's concerns, and then find people to test the drug.
Anyway, there are plenty of homeless people on the streets of North America, so why worry about not finding the tools for drug testing?
"My time is running out."
Benson thought to himself.
After landing, the group exited the VIP channel and boarded several business vehicles, heading straight to Senlian Science and Technology Park.
This was the first time in Benson's life that he had set foot on Chinese soil.
He was observing the city through the car window.
Throughout the journey, I felt anxious and uncertain.
Whenever he wanted to question NeuroGuard, a voice would pop into his head: the other party has Deep Blue Battery, Super Rice 2000, Ora Gold 940 and Mengjie Sponge. A company with several Nobel laureates can create a new drug. This makes perfect sense.
About forty minutes later, the convoy drove into the Senlian Science and Technology Park.
Benson eagerly got out of the car and saw a woman in her early thirties, dressed in a suit and looking like a secretary, standing opposite him.
“Mr. Benson, I am Meng Yun, Mr. Chen’s assistant. Please come with me.”
After a brief introduction, Meng Yun led Benson and his medical, legal, and bodyguard staff into the elevator lobby and onto a conference room on the top floor.
As soon as Benson sat down, he heard a series of very harmonious footsteps coming from outside the door.
The force, landing point, and sound of each step were exactly the same.
He turned his head and saw a young man in his early twenties, dressed in a suit and tie, with a dignified air, slowly walking towards him.
In Chen Yansen's eyes, Benson was the best test subject and living advertisement for Brain Shield!
At this moment, the two of them were heading in opposite directions.
(End of this chapter)
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