Mizuki and Kakashi had discussed this issue before. When Sasuke was first cursed by Orochimaru, Mizuki's strength was slightly worse than Sasuke's current strength, and he was powerless to change anything. It was not until he got the complete curse seal technique from Kabuto Yakushi that he was able to operate and control it. Unfortunately, time has passed, and some things are too late.

"Now is not the time when I mentioned the solution to the curse seal. One move could affect the entire system. Kakashi, it's time for you to know some things..."

Mizuki sighed and said with some regret.

"I'm all ears."

"Not long ago, I carefully reviewed the statistical data collected by the village, especially the situation of ninja casualties in the village since Lady Tsunade implemented medical reforms, and found some very special phenomena..."

Kakashi had no idea why Mizuki changed the subject, so he didn't interrupt Mizuki and just listened patiently.

"With the establishment of a mature medical ninja system, the casualty rate has dropped dramatically. But there is a puzzling phenomenon that has been bothering the intelligence department. The death rate of ninjas with bloodline limits is much higher than that of ordinary ninjas..."

"There is a view that because bloodline limit ninjas are so powerful, they often have to carry out dangerous missions, which pushes up the casualty rate. This is of course also an explanation. The greater the ability, the greater the responsibility. This is not surprising..."

"Compared to ordinary ninjas, the number of ninjas with bloodline limits is too small, and the statistical sample is low, so there is a possibility that the results are distorted."

"But I think all of this is just an appearance. After carefully looking through the resumes of most of the bloodline ninjas, I found a very worrying situation. The death rate of these chosen ones outside of combat is much higher than that of ordinary ninjas..."

"Outside of combat?"

Kakashi asked, somewhat confused.

"Most of them died of illness. Even if they didn't have serious illnesses, most of them died early. The average life expectancy is lower than that of ordinary people in the ninja world."

"Is there such a thing?"

Mizuki nodded gently.

"The higher the bloodline limit, and the younger the age of awakening, the more serious this phenomenon is. This does not make sense with the previous explanation."

"Why hasn't anyone mentioned this before?"

"Ninjas are always fighting in wars where their lives are in jeopardy. They don't have time to pay attention to such things. Only Konoha has preserved some information because of practical needs."

Perhaps only Mizuki and Orochimaru could realize that ordinary ninjas don't care how old they can live. There are very few ninjas who die of old age.

There are two most obvious examples. Kaguya Kimimaro, who possesses the Corpse Bone Vein, and Uchiha Itachi, both of whom awakened their Bloodline Limit when they were very young, and both of them ended up with incurable illnesses.

What kind of disease would be difficult for the ever-changing medical ninjutsu? It would be too rare for even Orochimaru to be unable to cure it.

Only congenital diseases brought from the mother's womb can make people helpless. Uchiha Itachi and Kaguya Kimimaro naturally did not have congenital deficiencies, it was only possible that the changes after birth damaged the foundation of their bodies. The so-called evaluation that God is jealous of talented people is really too taken for granted. God is not so stingy that he will be killed just by opening the blood limit.

"You mean, the curse seal is related to Sasuke's bloodline limit?"

Kakashi finally understood what Mizuki meant.

"It's not just the curse, the almighty potion is also involved. Both are means of squeezing the body's cells and exerting their full power. The almighty potion has a short but fierce effect, while the curse is slightly slower, but long and difficult to remove, and will drag people into the abyss step by step."

As long as Shuimu's potion lasts, at most he will lose some lifespan. But if the curse is not restricted, it will really kill people.

"Is it serious?"

Mizuki smiled helplessly.

"I have a piece of news for you. Sasuke's Sharingan has been opened for several years, perhaps even earlier than Uchiha Itachi. Do you know what this means?"

This doesn't mean that Sasuke will face the same desperate situation of physical collapse as his brother in the future, but this possibility cannot be ruled out. Under the stimulation of the Mizuki potion, the chance of physical problems is increasing.

"How is that possible? There has never been any sign of this before!"

"You have the Sharingan yourself, so you should have noticed it, right?"

Mizuki pointed at Kakashi's left eye which was covered by the forehead protector.

"You should be able to use the Mangekyō Sharingan soon."

"You know all this? I only noticed the changes recently."

Shuimu sneered softly.

"The eyes are windows to the soul. The Sharingan is a manifestation of the owner's inner strength. With strong emotional changes, the Sharingan can be activated and upgraded. But emotions and will are not enough. You must have enough chakra to use it. Now you are almost used to the more advanced Sharingan, and the amount of chakra is barely enough. Sasuke is in a similar situation to you. His young body has activated the Sharingan, but there is not enough chakra to maintain it, so he himself is not even aware of it."

"That seems to make sense, but how did you know that?"

"A careful examination will reveal that Sasuke's health is not good right now. It is not clear whether there is a serious problem, but if we don't think of a solution, the consequences will be unpredictable!"

If Sasuke had joined Orochimaru, the situation might have been slightly better. Tsunade's medical ninjutsu was very strong, but that was all. When it came to the fundamental flaws, Orochimaru's methods were more reliable, while Mizuki's methods were too simple and crude.

"If I take action, it will either go against Sasuke's wishes or against your wishes. It's a dilemma!"

"So serious?"

"You know shogi, right?"

Kakashi nodded.

"Infantrymen with few ways to retreat can only move forward steadily. After breaking through numerous obstacles and reaching the bottom line, they will be promoted to full-fledged infantrymen, from dispensable cannon fodder to important generals. Of course, there is another option, which is to completely remove the curse seal. Sasuke will be weak for a long time, and will not be able to move forward for at least two or three years. Do you think he will accept it?"

The main part of the Tiger Curse Seal on Mizuki's body was on the original Mizuki's soul, and he was weak for several months after being peeled off. To completely remove the Heaven Curse Seal on Sasuke, one can only tear off a part of his soul. Mizuki is sure that he can survive, but he can't guarantee that his strength will not decline.

Kakashi fell into deep thought after hearing what Mizuki said, and Mizuki said:

"You should discuss this with Lady Tsunade, maybe there will be a better solution. I still have to go to the Bear Country to clean up those fish that have slipped through the net."

In the past, the task of wiping out the peripheral forces of the Akatsuki organization was the responsibility of Kakashi, but now it has become Mizuki's responsibility.