Chapter 454: If You Can’t Make Money, Why Develop Drugs? (Part 2)
Although Anmos wanted to serve County Mayor Lin and contribute his strength to repay County Mayor Lin for saving his life.
But his expression completely betrayed him.
"I can't do that."
Lin Wen understood this classic expression at once.
Isn’t your biotechnology very strong?
All kinds of mutant humans have been created, so why can't it be cured of cancer?
Hearing this question, Anmos gave an understanding smile.
This is obviously another accident where amateurs directed the professionals.
This is very common in the field of scientific research.
Although the Qin Group has great respect for science, this kind of thing still cannot be avoided.
In his opinion, the best leader should let researchers do their work without asking about the results, without counting the investment, and without setting a deadline.
The next level of leadership only cares about results.
The next level of leadership asked for results, set deadlines, and blocked investment.
The worst leader is the one who directly interferes in scientific research.
Although the mayor of Changshan County is kind and benevolent, he obviously has the bad habits of those leaders, pretending to know everything and being half-baked.
"Head of County Lin."
Anmos said kindly.
"We are able to edit genes and create monsters that do not exist in nature because the great mentor Li Man discovered the genetic code and the workings of protein life. We can make certain adjustments to life in this dimension."
"However, cancer is a progenitor of life's genes, and its greatest characteristic is its ability to deceive the immune system. Our research in this area is still incomplete."
Lin Wen said, "Wouldn't it be enough if we just don't let it deceive us?"
Anmos patiently explained, "What County Mayor Lin is talking about is immunotherapy. Currently, there are cancer vaccine therapies and monoclonal antibody therapies, but what you are talking about is not letting cancer cells deceive you, which is very difficult to do."
"Why?"
Anmos said, "Sheriff Lin, you should know that the human immune system is the root cause of the cure for most diseases. Drugs are only a means to control pathogens."
"Immune cells are like guards, constantly patrolling our bodies, killing invading enemies and protecting our safety."
"These immune guards recognize enemies primarily through proteins."
"If I were to use an analogy, common pathogens are like thugs, and cancer cells are top spies. They release special proteins to disguise themselves as normal cells, or they reduce the ability of immune cells, or they use a special protein called cluster of differentiation antigen 271 to trigger immune cell suicide."
"Cancer cells use these methods to protect themselves, absorbing nutrients from the host and proliferating wildly. By the time we are able to detect cancer, there are already billions of cancer cells."
"At this point, the immune system has basically failed, and cancer cells can only be controlled through external means, such as surgical resection, laser, microwave, and targeted drugs."
"Johnson & Johnson's targeted drugs are the best. They can even cure mid-stage cancer, but they're too expensive."
"In the late stages, cancer cells spread throughout the body, intermingling with normal cells, corroding the body, stealing nutrients, disrupting order, and killing guards. This leads to a decline in immune function, foreign invasion, and incurable disease. Ultimately, the patient dies from organ failure and multiple complications."
Lin Wen said, "We release a protein that specifically marks cancer cells, leaving them nowhere to hide and allowing them to be chased and attacked by immune cells. Isn't that enough?"
An Mosi had a headache. He was most afraid of leaders who only had half the knowledge.
"Chief Lin, the human immune response mechanism is very complex. The protein you are talking about is called a pattern recognition receptor protein."
"They can recognize a lot of specific information, such as the structure of bacteria and viruses. These are not inherent to the body. Once recognized, the receptor protein marks them as enemies and transmits signals downstream, activating the immune response and mobilizing immune cells to eliminate foreign invaders."
"Currently, there are no receptor proteins that specifically recognize cancer cells. All receptors have very low recognition of cancer cells, so the immune system is very inefficient in eliminating cancer cells. Once an immune storm is provoked, the lethality to the body itself is even higher."
Lin Wen asked, "Can't you process protein?"
Anmos replied cautiously, "Yes, to a certain extent."
"The receptor protein is like a radar. Cancer cells are characterized by telomere loss. Couldn't you just modify this radar to specifically recognize telomeres?"
An Mosi fell silent. This opinion was too professional and didn't seem like something an outsider could say.
He thought for a moment and said, "Chief Lin, even if this transformation is possible, it will be extremely difficult and will not be completed in a week."
"how long?"
"It could be as short as three to five years, or as long as more than ten years."
Lin Wen asked: "What is your method for modifying proteins?"
"There are many options," said Ammers. "Specifically, in this area, we usually use a receptor protein with similar functions and then make some structural adjustments... This is a very large project. Just finding the right receptor protein can take many years, and there is always the possibility of failure."
Lin Wen closed his eyes for a moment, then opened them again, his eyes gleaming with confidence. He said, "Use the epitope differentiation cluster 911 protein for transformation."
"ah?"
An Mo Si was stunned for a long time before he remembered this unconventional protein.
"Isn't that a differentiation protein related to cardiac enzymes? Would it make sense to use it for modification?"
Lin Wendao: "That makes sense. Its subunit helical structure is very suitable. With only a small amount of processing, it can be transformed into the protein receptor we need."
"But...but..." An Mosi choked for a long time before asking, "How can we mass-produce it?"
Lin Wen closed his eyes for a moment and continued, "Use No. 281 beta-aminoacidase to coat the modified protein. Place it in a sterile aqueous solution at a constant temperature of 21.74 degrees Celsius, store it in a specific ratio of air for thirty hours, and then hydrolyze it with the enzyme to obtain a large amount of active receptors for the protein."
An Mosi opened his mouth wide, his eyes bulged out, and saliva flowed directly from the corners of his mouth into his neck, making him look like a person with congenital mental disability and acquired cerebral palsy.
"Hey." Lin Wen poked him, but there was no response. "What's wrong with you?"
An Mosi ascended into the sky.
The field of biochemical research is like a boundless dark ocean.
Everything you see is unknown, with turbulent waves and full of danger.
The pitch-black sea seems like a bottomless abyss, hiding terrible monsters.
And they drove the small boat and explored in such an environment without any direction.
Lin Wen's appearance was like a ray of light across the sky, splitting the darkness. Like a lighthouse on the coast, it guided their way forward.
“The worst kind of leader is the one who meddles with research.”
No.
Anmos has now changed his mind.
That is godly leadership.
“Wow, hahaha!”
An Mo Si suddenly jumped up in anger, which scared Lin Wen.
"I understand."
"I understand."
"Sheriff Lin, you are a genius, the Leary of biology, the Lyman of biochemistry. Your becoming sheriff is a loss to humanity..."
Lin Wen interrupted him: "Can you do it?"
"able."
"How about a week?"
"OK!"
“What is the estimated cost?”
"Ten million."
"Go ahead and do it."
"good!"
An Mosi jumped up, took two steps, and suddenly turned around.
"Chief Lin, I have another question."
Lin Wen said impatiently: "Solve it yourself, your soul is almost gone."
"What is the Yuanshen?"
"A kind of wisdom."
Lin Wen answered casually, not wanting to destroy the scientific atmosphere.
"By the way, how much does it cost to mass-produce this drug?"
Anmos replied, "One gram is between 100,000 and 300,000, depending on the efficiency of the hydrolysis."
“Is it useful for advanced cancer?”
"Yes, we can significantly enhance the immune system and send patients to the intensive care unit to maintain their lives. With our current capabilities, even if a patient is on the verge of death, we can still save them and cure them completely. A large number of floating receptors will remain for a long time, preventing new cancers from recurring."
"Okay." Lin Wen nodded and asked, "How much is Yu Zhongxian's medicine?"
"A course of treatment costs about 1.5 million yuan, and usually three courses are required."
"What about ours?"
"One course of treatment is enough, and the cost is around one million. I suggest we set a reasonable price, ten million will be enough. If the price is set too high, people might accuse us of taking advantage of patients."
"Okay, the price is ten thousand."
Lin Wen turned and walked out.
Behind.
Anmos became demented again.
After a long while, he was finally shaken awake by an assistant.
"Dr. An, Project Number Seven is about to expire!"
An Moss didn't care about Project No. 7 at all. He grabbed his assistant and asked the question he had been thinking about for a long time but couldn't figure out the answer to.
“If it doesn’t make money, why develop drugs?”
——
After leaving the biochemical base, Lin Wen plunged into his busy work again, but calls from the highest military headquarters came one after another, all urging him to hold a military expo as soon as possible.
Lin Wen had no choice but to set the date for three days later.
Three days later, the good karma of this week will be settled.
Hope it can bring him one or two good lucks.
In addition, he will also prepare to establish a Changshan County Science Academy.
Otherwise, it is difficult to say where these technologies came from.
Moreover, if it were all relying on [Asking the Way to Heaven], this soul really couldn't withstand it.
Lin Wen had already put all his efforts into the drug development plan just now.
Understand all the information clearly, figure out the most critical points of the problem, and ask very targeted questions.
Under such conditions, his spirit was still used up.
Therefore, it is very necessary to establish a scientific research system.
We can't rely on magic to solve all problems, right?
Even a true immortal cannot withstand such consumption.
However, the establishment of the Academy of Sciences had to come second.
The first thing he has to do now is to pound the ground, then dig the mountain, and then dig the subway.
After all this is done, a lifeline transportation line will be built across Changshan County from east to west.
Moreover, while building, we must also find time to defeat Yu Zhongxian.
The first thing to do is to destroy his economic lifeline, squeeze out his industry, and strip him of his power.
Then try your best to help Li Longxing win, obtain enough capital, and take away Yu Zhongxian's fundamental power in one go.
Finally, it is the most exciting moment.
Yu Zhongxian was bound to be disobedient and desperate, so he took a gamble and led his core members to rebel and escape.
At that time, it will be time for Lin Wen to appear.
He will fly over like a god, punch his stinky face, and crush this bug that has been bothering him for a long time.
After that.
No one will interfere with the development of Changshan County anymore.
Lin Wen is very much looking forward to such a future.
——
To the Winter Palace.
A chairman of the review was respectfully reporting the industry income to Yu Zhongxian.
"Mr. President, the pharmaceutical group's revenue this quarter has reached 50 billion, exceeding our revenue in any previous period."
"That's right," Wang Xinwei said with a flattering smile. "Your decision to raise the prices of essential medicines was a brilliant one. Although we faced a lot of criticism for a while, it didn't affect the overall situation. No one is immune to the fear of death."
Priest Dror smiled and said, "When a dog is hungry, it will come back. When a man is dying, he will bow his head."
"The fear of death will make them hand over all their money."
"Ha ha."
The hall was filled with a sea of joy.
Yu Zhongxian's complexion improved slightly. The recent series of blows made it difficult for the council to move forward.
Fortunately, Johnson & Johnson's research and development base and pharmaceutical company have saved the situation somewhat.
“How’s the new cancer drug development project going?”
Priest Dror replied, "Our progress is excellent. We will soon conquer brain cancer and destroy the last remaining stronghold of cancer."
Wang Xinwei asked, "What's the appropriate price for new drugs?"
Yu Zhongxian said calmly, "Three million, plus a contract. If you can't pay, you can sell yourself to the Council to pay off your debt."
"Great!" Everyone cheered in unison: "This is a good idea!"
"Mr. General is truly kind and benevolent, and his merits are immeasurable!"
Yu Zhongxian raised his hand to stop the flattery and asked, "What about the late-stage cancer project?"
Wang Xinwei replied: "Progress is slow, and we need a lot of funding to achieve results."
Yu Zhongxian was silent for a moment.
"Then invest another 10 billion."
The third update was before 23:59:59
(End of this chapter)
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