While eating, I chatted with Teacher Tan about scientific research.
Mr. Tan is a laparoscopic expert, a general surgeon, and a gastrointestinal tumor specialist. Mr. Tan’s traditional and laparoscopic surgeries are first-rate, and his extraoperative treatment plans for tumor patients are also top-notch.
It is ridiculous to imagine that the scope of academic research that Professor Tan can do is limited to laparoscopy. It is like the immortal brother rarely performs heart transplant surgery, but studies assistive devices for end-stage heart treatment.
For surgeons, surgery is an advantage in scientific research, as they can conduct research on various surgeries. On the other hand, surgeons have advantages in basic disciplines, mainly referring to the advantages of pathological specimens obtained by surgeons.
It is too easy for surgeons to obtain surgical pathology specimens of various patient tumors during surgery. Unlike other departments, it is very difficult to obtain pathology specimens as desired. The specimens obtained by laparoscopic examination in internal medicine are limited in scope and far inferior to those in surgery. In this way, you will find that surgeons who are engaged in basic research can actually be on par with internal medicine doctors and pathologists, or even better.
Teacher Tan happens to be such a big shot.
Specifically speaking of the topic that Professor Tan is researching, we can say that it is a class of star anti-tumor drugs that has become famous since the 21st century: targeted drugs.
Targeted drugs are like arrows aimed at tumors. Compared with chemotherapy drugs, which attack tumors like spraying pesticides, targeted drugs are highly accurate and avoid harming healthy human tissues. They are warmly welcomed by doctors and patients. The advantage of targeted drugs lies in their accuracy. The basis of the accuracy of targeted drugs lies in the target. Finding the target of targeted drugs naturally becomes the top priority of scientific researchers.
The study of targets is essentially inseparable from the study of the pathogenesis of tumors.
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The pathogenesis of tumors is complicated, and there are many links and substances involved in the pathogenesis of tumors, all of which can theoretically become targets. For example, the most common substance receptors, transporters, enzymes, ion channels, genes, etc., many of which are basic research topics that have been studied. Here is a relatively new research topic that was discovered and proposed in recent years, called microRNA.
To put it simply, microRNA can be said to be a substance similar to intestinal flora. Good microRNA can inhibit tumor tissue after being absorbed by humans. Bad microRNA promotes the growth of tumor tissue. Based on this principle, if medical oncology studies the former, it can be made into a tumor inhibitor. If you want to deal with the latter bad thing, it is most appropriate to make a targeted drug that "shoots" and strikes.
Medical discoveries show that it is better to kill tumors than to suppress them. According to the information Xie Wanying learned from people who came back from the future, targeted drugs for microRNAs are a new trend in the future.
Anyway, as mentioned before, to develop targeted drugs, you must first find the target, and to develop RNA targeted drugs, you must find the microRNA. Professor Tan’s key research topic is to study colon cancer microRNA, and he has discovered a new microRNA in a wide range of colon cancer specimens. In theory, it can become a target for new targeted drugs for colon cancer, which is a key area at the forefront of oncology research in the world.
Teacher Tan’s research project is so cutting-edge that Xie Wanying would definitely say that she cannot interfere with her teacher’s research.
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