In fact, penicillin itself will not cause allergies. What really causes allergies are the impurities produced in the penicillin culture medium.

This is also why later generations did not need to do skin tests when using penicillin abroad, because they used synthetic penicillin without impurities. But this is too expensive, so it has not been promoted in China for a long time...

The purity of penicillin synthesized by the traditional method of Jiangnan Medical College is worrying. The probability of allergy is definitely high, so a skin test is of course necessary.

Fortunately, the skin test results showed that the emperor was not allergic.

Li Shizhen immediately gave him a penicillin infusion. He was very nervous as he watched the transparent liquid in the glass bottle being injected drop by drop into the emperor's body.

He was not worried about the drug's ineffectiveness. On the contrary, he was worried that the drug was too effective, and a large number of Portuguese pathogens would be killed in a short period of time, releasing a large amount of "toxins", which would make the patient's condition worse, or even endanger his life.

This situation had occurred before when Jiangnan Hospital used mercury and arsenic to treat syphilis. Because it was discovered by head nurse Wang Tiedan, it was named the "Tiedan reaction." In clinical trials, it was found that this phenomenon also occurred when penicillin was used for treatment, and it was more severe...

So the two deans were very nervous and stayed beside the emperor, ready to provide first aid at any time.

Sure enough, half an hour later, the emperor developed symptoms of high fever, sweating, and vomiting, accompanied by a sudden drop in body temperature, cold limbs, and even coughing up blood.

The emperor's miserable condition frightened Empress Li, who was attending to him, so much that she screamed and told them to stop using the medicine immediately!

"It's no use stopping now. We can only help the patient to get through it." The two miracle doctors remained unmoved and used acupuncture and massage to help the emperor relieve his symptoms.

Fortunately, the eldest princess was present and forcibly helped the stimulated Concubine Li out of the inner chamber.

When they saw the empress come out, Gao Gong and others who were nervously peeking outside quickly knelt down and bowed their heads.

But all he saw was the pair of pointed phoenix-head shoes with ingot-shaped soles, which stopped in front of Gao Gong.

"You, you, you have harmed the emperor so badly, how dare you still live!" Concubine Li glared at Gao Gong, as if she wanted to bite off a piece of his flesh.

"I, this old minister, deserve to die, I deserve to die..." Gao Gong did not argue, he just kowtowed repeatedly. Soon, a bloodstain appeared on the Suzhou imperial kiln gold brick.

After the princess helped Concubine Li into the west room, Zhang Juzheng and Zhao Hao hurried to help Gao Gong up. They saw that his face was covered with blood and tears, and he looked extremely sad and horrible!

"Mr. Yuan, don't blame yourself too much..." Gao Yi hurriedly advised: "You are also doing this for the good of the emperor..."

"Bullshit!" Empress Li happened to hear this, and the daughter of a bricklayer was so fierce that she cursed Gao Gong through the curtain, "The emperor respects him as a father, but he has always used the emperor as a tool! Otherwise, he would have kept stuffing low-class people like Chen Hong and Meng Chong around the emperor! Otherwise, the queen would have invited the genius doctor from Jiangnan Hospital, but he would have stopped him and replaced him with his own mediocre doctor? How could he care about the emperor's illness? He has always only considered his own power!"

Feng Bao badmouthed Gao Gong and Meng Chong in Li Guifei's ear all day long, and even pushed the responsibility of Altan Khan presenting Hua Hua Nu Er to Gao Ge Lao. He said that Gao Gong had colluded with Altan Khan a long time ago and helped the old Tartar to seek the title of king. The old Tartar sent a batch of coquettish Tartars to Gao Gong as a thank you. But Gao Gong was old and could not afford them, so he presented them to the emperor to consolidate his favor. Among them was Hua Hua Nu Er...

What kind of knowledge could Li Caifeng have? Of course, she believed whatever Eunuch Feng said. Eunuch Feng was wholeheartedly protecting her and her mother, so how could he have any bad intentions?

Empress Li naturally hated Gao Huzi to death because of the constant criticism.

~~

Outside the pearl curtain, one could hear Empress Li's curses becoming more and more unpleasant, almost catching up with the slang of a village woman.

"Your Majesty, calm down!" Zhang Juzheng had no choice but to persuade her, "Please take the emperor's health into consideration first."

"You..." Empress Li was about to scold this nosy guy, but after seeing the face of Mr. Zhang clearly... Damn... so handsome!

The handsome Zhang, who exudes the charm of a mature man, makes all the old men, eunuchs and teenagers become passers-by.

Well, you are handsome and you are right...

Li Caifeng could not help but change her tone to a gentle one and said, "You are Mr. Zhang, right? I have heard from Mr. Feng that you are as handsome as Pan An... and as kind as Bigan. I will rely on you to make decisions."

Gao Yi felt like vomiting blood when he saw this. This was a blatant collusion between the inside and outside! Besides, Gao Ge Lao had already fallen, so how could he fight against them?

Oh, what's wrong with me? Isn't this a mental retardation... Oh no, in the 23rd year of Zhizheng, did I join Chen Youliang?

Zhang Juzheng led his officials out and waited anxiously under the pavilion...

At dusk, good news came from inside that the emperor's symptoms were under control.

By the second half of the night, the emperor's temperature began to drop. At dawn, the rash gradually improved...

By the morning, Longqing's vital signs had completely stabilized.

Wan Mi Zhai, who hadn't slept for a day and a night, came out to announce that the emperor was basically out of danger. He would continue to receive intravenous treatment for fourteen days, of course, mainly garlic extract...

But because of brain damage, no one can tell when the emperor will wake up.

Fortunately, Jiangnan Group had accumulated rich nursing experience on Lin Run. The disciples brought by Li Shizhen immediately began to prepare various life-sustaining methods such as oxygen production and nasogastric feeding. This once again opened the eyes of Jin Yuanpan of the Imperial Hospital and the famous doctors of the Zhairen Medical Association.

Now they finally believe that it is not that Jiangnan Hospital is unique and innovative, but that it is already far ahead and they can't catch up.

However, the doctors of Zhairen Medical Association are most worried about their own lives...

If Li Shizhen had not said that he needed their help, the domineering Empress Li would have already thrown Feng Bao and the others into the imperial prison.

In fact, the new medicine of Jiangnan Hospital has transcended the system of traditional medicine, and they can't help at all. Naturally, they know that this is Doctor Li helping them to atone for their sins and seek a way out...

~~

The next few days were extremely torturous. No one dared to leave Jujing Pavilion, waiting for the result in fear.

The princess felt sorry for her godson and son-in-law, so she asked Eunuch Ji to take good care of Zhao Hao. But why should Eunuch Ji worry? Eunuch Feng loved this little Zhao Hao to death, not to mention Old Zhang and the two sick old men, so he asked people to clean up the adjacent Feicui Pavilion for them to rest.

But who else but Duke Cheng could sleep peacefully? These old men were not in good health to begin with, and they would collapse after a few days. So they decided to take turns to stand guard outside the Jujing Pavilion at night, and those who were not on duty could sleep peacefully, thus achieving sustainable waiting.

Lord Gao gradually calmed down, and that night it was his turn to keep watch with Zhang Juzheng.

The garden was brightly lit, with night patrols by imperial guards and eunuchs and palace maids coming and going. Gao Gong pulled himself out of the confusion and pain in front of him and entered a pure state. Then he calmly said to Zhang Juzheng:

"Uncle, no need to wait, you win."

"Mr. Yuan?" Zhang Juzheng was stunned for a moment, then he understood that what he meant was that there was no need to wait for the emperor's final condition.

Regardless of whether Longqing was dead or alive, or half dead, he had decided to give up the throne...

"Mr. Yuan, I never thought of competing with you." In fact, Zhang Xianggong also knew that he would definitely win. He had already calculated various possible developments in the past few days. In each case, Gao Gong would be eliminated. The only difference was how much effort he put in.

He was also about to win, and his words were kind: "Bugu really wants to work with Yuan Weng to correct the chaos and create a prosperous era."

"What a pity, fate plays tricks on us." Gao Gong waved his hands, not wanting to review with him how he lost. He said in a deep voice: "Don't persuade me, don't comfort me, that would be an insult to my intelligence, and would make me look down on you. Now that things have come to this, we can only look forward. Since you haven't forgotten our Gao Kui agreement, I will ask you to do a few things, you must do them!"

"Please speak, Mr. Yuan." Zhang Juzheng had no choice but to listen attentively.

"I am criticized for being hasty and reckless in my work, and I don't deny it. But I still say that I have no selfish motives. I just want to restore order and save the Ming Dynasty, and create the 'Longqing Reign'! So, uncle, please don't tear down the foundations of the past few years because of me. Since we share the same ideals, can we not follow the old path of the death of the leader and the end of the government?"

"Sure... I mean, no matter what, I will support Mr. Yuan's strategy." Zhang Juzheng said this with some sincerity: "No matter what time it is, I still say that when it comes to reforming the old and establishing the new, and building on a high-level perspective, I am not as good as you!"

"Okay, then the first three things you should do as a new official are to focus on administration of officials, taxation, and mergers. I'm not asking you to do them all at once, but you must make a general outline and lay out the theme for the big article in the future," Gao Gong continued.

Zhang Juzheng was secretly unhappy, thinking, who will be the Prime Minister? But he still looked humble and listened to Lao Gao opening the conversation:

"In the past few years, my main focus has been on pacifying the four directions and eliminating dissidents. My only goal is to create a favorable environment for the next reform." Gao Ge Lao said with infinite regret: "At the beginning of this year, I originally planned to let go and make some progress. The top priority this year is the reform of the civil service system. This is why I have been shamelessly in charge of the Ministry of Personnel. No one will do anything that offends people, so I have to do it!"

"So, Yuan Weng's petition at the beginning of the year on behalf of the Ministry of Personnel requesting that 'officials from the two capitals should not take sick leave to avoid being posted outside' was a foreshadowing?" Zhang Juzheng said suddenly.

"Yes, it's a pity that the emperor's illness has delayed everything." Gao Gong sighed, cheered up and said: "Now the Ming Dynasty is plagued by a myriad of problems, and the key lies in the administration of officials. The administration is unclear, corruption is rampant; the government is incompetent, mergers are rampant; officials are perfunctory, and government orders are meaningless. So no matter what you want to do, you have to start from here first!"

"Yes, I agree with you." Zhang Juzheng nodded. He had heard it thoroughly and asked humbly, "What good ideas do you have, Mr. Yuan?"

"I won't talk about the old sayings like rewarding and punishing people, verifying the names and facts, etc. You are definitely better at it than me." Then Gao Gong said in a shocking voice: "I will give you three suggestions. As long as you listen, you will be able to wipe out the two hundred years of decline in the officialdom and bring vitality to the Ming Dynasty!"