moment……
The entire laboratory fell silent, and the doubts on the researchers' faces turned into astonishment, and then into some kind of unbelievable deep shock.
They originally thought that the young billionaire was just daydreaming, or was just trying to make some political show, so he was hanging out in his backward medical laboratory on a whim.
Who knows, after a few days, when the novelty wears off and the news effect is too much, he will completely leave Kangsheng Pharmaceutical and never set foot there again.
However, the plan that Lin Huowang came up with was far beyond their comprehension in terms of its detailed details, logical rigor, deep understanding of organic synthesis technology, and especially the pharmacological ideas that broke away from the limitations of the times.
Everyone knows very well that this plan is definitely not something that an outsider could make up out of thin air!
Especially the subtle design of these molecular formulas and the precise direction of these reaction conditions, any one of which is enough to write a paper in a top international journal.
Faced with everyone's astonishment, Lin Huowang smiled, feeling a little fortunate. Before his reincarnation in his previous life, he was discussing with his investment managers about investing in or building a generic drug company in the country, and the main Western medicine being imitated was sildenafil, commonly known as "Viagra".
The birth of sildenafil can truly be considered a major blunder. While researching a drug to treat angina in the 1980s, Pfizer scientists unexpectedly discovered that sildenafil, while having a modest effect on dilating coronary arteries, was surprisingly effective in treating a certain side effect in the subjects.
As a result, many male subjects refused to return the sildenafil tablets they had received. Even after the experiment was over, they frequently came to the researchers and asked for these small blue tablets at high prices just for the "side effect" of aphrodisiac effects.
It wasn't until the late 1980s and early 1990s, after the PDE5 enzyme was isolated and identified, that researchers suddenly understood the true value of this "side effect." It truly was a remarkable, unexpected invention, saving countless impotent men worldwide.
What Lin Huowang has to do now is to create this unexpected "result" ten or twenty years in advance, and to achieve that "unexpected" effect within the "hypothetical" framework of reverse engineering, using a logic that seems to be looking for a "pressure relief valve" vasodilator.
Based on this, he was able to cleverly avoid the PDE5 target, which was not yet known at the time, and package it into a more potent vasodilator that specifically acts on blood vessels in specific areas.
While Lin Huowang explained the principles and processes to these biomedical doctors with some reservations, he also began to quickly plan in his mind the layout after the subsequent drug development.
First of all, we must avoid possible patent traps and apply for "new pyrazolopyrimidinone derivatives for the treatment of cardiovascular diseases" as the core patent.
The structural formula of the compound must also be written with extreme precision, covering sildenafil and all its key salt forms, such as citrate, so that the scope of protection of the core patent applied for will be as broad as possible.
As a reborn person, Lin Huowang knows that the time difference is his biggest weapon for making huge profits. He must build such a solid patent barrier before the Pfizer team abroad actually starts related research.
By then, even if Pfizer developed a similar drug, it would face prosecution for infringement by Linhuowang. As long as the patent barrier is established first, then for decades to come, this will be Linhuowang's exclusive business.
Even if other pharmaceutical companies want to produce drugs with similar effects, they must purchase patent authorization from Lin Huowang, of course... except for the incredible India.
Of course, in addition to patent barriers, the key intermediates in the synthesis route of sildenafil, such as the preparation process of UK-, should be kept confidential as much as possible.
At Kangsheng Pharmaceutical, laboratory records must also be kept somewhat ambiguous, creating technical obstacles and increasing the time and difficulty for competitors to reverse engineer their software. Every researcher in the lab must sign a confidentiality agreement; breaching the agreement could result in astronomical claims.
The most important thing is the global layout. After the first patent application in Hong Kong, applications must be submitted immediately through the Patent Cooperation Treaty to key markets such as the United States, Europe, and Japan.
Especially in the United States, which is the largest market for sildenafil in the future, Lin Huowang knew very well that he could not point out the "aphrodisiac" effect of the drug before applying for a patent. Otherwise, with the American bandit-like style, he would not approve the patent application so easily.
Lin Huowang was clever. He first subtly hinted in the application documents about its potential in "promoting local blood circulation" and "improving peripheral vascular function", leaving a certain foreshadowing for the future shift to "that" indication.
Europe has stricter reviews of pharmaceuticals, requiring more detailed data, such as experimental evidence of changes in cGMP concentrations. This can be designed using existing high-performance liquid chromatography (HPLC).
In the clinical trials for applying for pharmaceutical patents and production licenses, Lin Huowang did not dare to blatantly use the term "aphrodisiac" in his promotion.
Let’s refer to Pfizer’s route. In the early stage, it was positioned as an “experimental drug for improving peripheral blood circulation disorders”, and the target population could be patients with hypertension and angina pectoris.
However, questionnaires and observation indicators must be designed secretly in the experiment to evaluate changes in "erection quality/frequency".
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