There's no successful global precedent for extracting a pure, single, and effective aphrodisiac ingredient from these natural substances! Which molecules within those expensive animal-derived herbs are actually responsible? What are their specific pharmacological mechanisms?
I'm sorry, Mr. Xiaolin, but even the world's top pharmacology laboratories haven't fully figured it out! It's like looking for a specific needle in a huge black box. It's too difficult!"
The researchers present all nodded in approval.
A researcher wearing gold-rimmed glasses sitting in the corner even bluntly pointed out, "Mr. Xiaolin, with all due respect, the effect you describe—taking a pill beforehand and having it take effect in a short period of time, like a recharge—sounds like science fiction."
Global pharmaceutical giants like Pfizer and Merck, with billions of dollars in R&D funding and thousands of top scientists, have poured countless dollars and time into research and development, yet they still dare not claim to be able to create such a "miracle drug." "Xiao Linsheng, are you counting on a few Hong Kong University PhDs from our small temple here at Kangsheng? That's really... unrealistic."
The subtext of his words couldn't be more obvious. Even they themselves lacked confidence. Given Kangsheng Pharmaceutical's current strength and the level of their people, this was simply an impossible task.
Lin Huowang did not refute on the spot, but listened quietly to everyone's opinions.
After all, the doubts raised by these researchers are reasonable.
They are not time travelers, and these perceptions are entirely based on objective judgments within the limitations of this era.
Lin Huowang knew very well that they were not being lazy or resisting their new boss. They just didn't want to do useless work based on their own abilities.
After these people finished speaking, the entire laboratory fell into a brief silence, with only the low humming of some old equipment when it was running.
At this time, Lin Huowang slowly raised his head, his eyes swept across the faces of those who did not trust him very much, and finally stopped with a smile on his face, Zhao Shengji, the leader.
Lin Huowang was not angry, nor did he make any additional excuses. He took out a thick manila folder from his briefcase and said:
"What you all say is very reasonable and objective. From ancient times to the present, the aphrodisiac components of natural medicinal herbs are indeed elusive and difficult to extract. Foreign giants have indeed invested huge amounts of money and have complex directions."
As Lin Huowang said this, he opened the folder and took out several pages of paper that had been prepared long ago and were densely covered with molecular formulas, chemical synthesis routes and experimental parameters.
“However, scientific breakthroughs often do not come from going around in circles in the known maze, but from finding new exits.
The key point you raised is that it directly affects the immediate response, which goes against the traditional pharmacological definition of 'aphrodisiac'. Excellent! So, why don't we change our approach? What if our goal isn't to forcibly 'enhance' something, but to—relax it?
"Untie?" A researcher was a little surprised by Lin Huowang's words. Not understanding what they meant, he repeated them subconsciously.
"Yes, it's about loosening up! The corpus cavernosum, a crucial part of the human body, requires blood flow to complete its function. The key to preventing this flow of blood lies in the tension of the vascular smooth muscle. This... target, what if we don't stimulate it directly, but instead eliminate the unnecessary constraints—that is, the excessive contraction of the smooth muscle itself?
Traditionally, "aphrodisiacs" are often stimulants or hormones, designed to forcibly "ignite" the engine. However, an engine stall may not be due to a lack of fuel, but rather a clogged exhaust pipe! The exhaust pipe is where the smooth muscles become overly tense, blocking blood flow.
We're trying to design a 'release valve,' an inhibitor that acts precisely on this specific area. It doesn't overheat the engine, it doesn't disrupt the body's hormonal balance; it simply releases the valve that restricts blood flow to that specific area when needed."
Lin Huowang grew increasingly excited as he spoke. He pointed to several key atomic groups on the paper and emphasized, "Look here, the skeletal structure of pyrazolopyrimidinone... This is the foundation. Some of its analogs already have certain literature documenting their vasoactive properties. Our breakthrough lies in the introduction of this side chain..."
The precise introduction of the methylpiperazine group into this skeleton is intended to optimize its water solubility and tissue specificity… and here, the sulfonyl group… acts as a ‘key’ in determining how the molecule binds to its target…”
Such professional terms, spoken by a "layman" like Lin Huowang, made the biomedical doctors present open their eyes wide and were all shocked.
However, Lin Huowang ignored everyone's surprise. He continued speaking while drawing on paper with a pen, outlining the possible binding sites between molecules and specific conformational changes.
Professional terms such as structure-activity relationship, side chain modification, specific binding, bioavailability, and metabolic pathway were all spoken fluently by him.
His remarks not only elaborated on the structural design concept of the drug, but he also directly presented the specific synthetic route sketch of "Viagra" in front of so many biomedical doctors.
From the selection of starting materials, to the synthesis of key intermediates, and the selection of solvents for subsequent reactions, and even the key nodes of temperature control, how to use existing equipment such as column chromatography and infrared spectroscopy to purify and identify the products at each step.
My dear, there is more to this chapter. Please click on the next page to continue reading. It will be even more exciting later!
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