"What breakthroughs have we made? Don't tell me we just adopted other people's methods."
"If it's only to this extent..."
Before Zheng Li could finish speaking, he turned to Li Miaomiao and asked, "Miaomiao, what is the annual budget for the Jiangcheng R&D Center?"
Without hesitation, Li Miaomiao replied, "The budget we prepared for them this year is 1.74 billion yuan."
Zheng Li nodded and said, "Okay, if this is all you're capable of, then cut the last bit of this year's budget."
Li Miaomiao asked, "Should we cut 740 million yuan?"
"Um."
After Zheng Li finished speaking, he looked directly at the R&D director sitting opposite him.
Each year, the budget for each R&D center is not only money and resources, but also represents your importance within the company.
Zheng Li's budget cuts do not mean that they will lower their R&D goals for this year.
The R&D director quickly replied, "Chairman Zheng, we have a lot of independent R&D."
He knew that what he presented could not be a shoddy job.
Zheng Li understood perfectly: when your boss knows too much about your work, the difficulty of slacking off at work is increased to the extreme.
"We optimized a neural network algorithm for molecular feature extraction from DNA sequences."
"Mr. Zheng, these are the individual's DNA sequence and molecular response variables in the genome."
“Traditional regulatory genomics methods mainly need to consider individual differences, while our optimized deep learning algorithm allows the genome to be flattened into a sequence DNA window centered on individual characteristics.”
"Then, by utilizing the differences within individuals, a large training dataset can be generated from a single sample."
"This is a one-dimensional convolutional neural network used to predict molecular features from raw DNA sequences."
"The filters in the first convolutional layer scan the pattern in the input sequence. Subsequent pooling reduces the input dimension, and additional convolutional layers can simulate the interactions of the DNA sequences in the previous layer."
"Look here again, in Figure c, the response variables of wild-type and mutant sequences predicted by the neural network shown in Figure b are used as input to another neural network that predicts variant scores and allows for the differentiation between normal and harmful variants."
"d Then, the convolutional filter is visualized by aligning the gene sequences that maximize the activation of the filter and creating sequence motifs."
"This is a mutation map of the sequence window. Rows correspond to the four possible base pair substitutions, and columns correspond to sequence positions. The predicted impact of any sequence change is color-coded."
"The letters at the top indicate the wild-type sequence, and the height of each nucleotide indicates the maximum impact of the mutation..."
After concluding her visit to the Lion City R&D Center, Li Miaomiao asked, "What do you think?"
"I couldn't understand a word he was saying."
"The Jiangcheng R&D Center has received increased internal resource support in the past two years."
"If their performance doesn't meet your expectations, we can transfer some resources to other, better-performing R&D centers."
Currently, Kechuang Bio has operations in Singapore, Wuhan, Suzhou, Nanjing, Shanghai, and London.
London and Shenhai mainly focus on the research and development of AI chips and brain-computer interface chips.
Research and development centers in the field of biomedicine are only located in Singapore, Wuhan, and Nanjing.
A large part of the outside world's impression of Jiangcheng is that it has a lot of universities, including two 985 universities and seven 211 universities, making it rich in educational resources.
However, Nanjing's educational resources are no less than those of Wuhan. Both cities have two 985 universities, but Nanjing has eight 211 universities.
The establishment of a research and development center in Nanjing by Kechuang Bio reflects not only the hopes of the Nanjing government but also its appreciation of Nanjing's high-quality educational resources and talent.
Zheng Li sighed: "I guess I'll barely pass."
"How should I put it? If this achievement had been presented to me as a highlight a year ago, when the Jiangcheng R&D Center had only been established for six months..."
“I would give them an eight out of ten, but now that a year and a half has passed, I can only give them a six out of ten.”
"What we've done is just a modification of what others have done; I haven't even asked them about the real underlying principles yet."
"The research is still only at the application level."
"The gap between us and pharmaceutical giants like Pfizer and Bayer is still too large."
Li Miaomiao thought to herself that, by Zheng Li's standards, the achievements of the Jiangcheng Research Center should be considered quite good in China.
Zheng Li's own research has always been groundbreaking, so he believes that groundbreaking achievements are to be expected.
However, in the field of biomedicine, the technological barriers of foreign giants are not so easy to overcome.
Of course, Li Miaomiao wouldn't say that openly; she whispered:
"These next few years will be used to train our team and cultivate talent."
"The talent development and research teams of giants like Pfizer and Bayer have a very long history."
"Respecting objective laws means that not all fields can achieve a leapfrog development."
"We just need to make steady progress."
While studying at the School of Economics and Management, Li Miaomiao heard many pessimistic opinions, believing that China would never be able to achieve breakthroughs and surpass others in science and technology.
Let alone technological breakthroughs and advancements, even breaking through in the industrial chain is extremely difficult.
During her student years, Li Miaomiao mostly heard pessimistic voices from those around her.
After starting their business with Zheng Li, they developed world-leading technology, which was at least five years ahead of the rest of the world.
Three years have passed, and Musk's Neuralink has yet to produce the brain-computer interface technology that CourseBio developed back then.
Having heard different opinions, Li Miaomiao was able to make a more objective judgment.
It is inevitable that China's science and technology will break through, but the road will be tortuous.
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